In vivo surface-enhanced Raman scattering techniques: nanoprobes, instrumentation, and applications
Kangwon National University · Harvard University · +3 more institutions
Abstract
Surface-enhanced Raman scattering (SERS) has emerged as a powerful tool in various biomedical applications, including in vivo imaging, diagnostics, and therapy, largely due to the development of near-infrared (NIR) active SERS substrates. This review provides a comprehensive overview of SERS-based applications in vivo, focusing on key aspects such as the design considerations for SERS nanoprobes and advancements in instrumentation. Topics covered include the development of NIR SERS substrates, Raman label compounds (RLCs), protective coatings, and the conjugation of bioligands for targeted imaging and therapy. The review also discusses microscope-based configurations such as scanning, widefield imaging, and…
Citation impact
- FWCI
- 19.94
- Percentile
- 100%
- References
- 156
Authors
4Topics & keywords
- Nanotechnology
- Raman scattering
- Materials science
- Multiplex
- Instrumentation (computer programming)
- Molecular imaging
- Preclinical imaging
- Computer science