articleNature Biomedical EngineeringFeb 12, 2025HYBRID OA

A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma

MBMattia BalleriniSGSerena GaliéPTPunit TyagiCCCarlotta CatozziHRHariam Raji

Istituti di Ricovero e Cura a Carattere Scientifico · European Institute of Oncology · +9 more institutions

PubMed
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Abstract

Patient responses to immune checkpoint inhibitors can be influenced by the gastrointestinal microbiome. Mouse models can be used to study microbiome-host crosstalk, yet their utility is constrained by substantial anatomical, functional, immunological and microbial differences between mice and humans. Here we show that a gut-on-a-chip system mimicking the architecture and functionality of the human intestine by including faecal microbiome and peristaltic-like movements recapitulates microbiome-host interactions and predicts responses to immune checkpoint inhibitors in patients with melanoma. The system is composed of a vascular channel seeded with human microvascular endothelial cells and an intestinal channel…

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55
total citations
FWCI
28.76
Percentile
100%
References
99
Citations per year

Authors

22

Topics & keywords

Topics
Keywords
  • Peristalsis
  • Melanoma
  • Immune system
  • Immune checkpoint
  • Biology
  • Cancer research
  • Immunology
  • Medicine
UN Sustainable Development Goals
  • Zero hunger
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