Phytochemical insights into flavonoids in cancer: Mechanisms, therapeutic potential, and the case of quercetin

Quercetin, a flavonoid known for its potent antioxidant and anti-inflammatory properties, has gained attention in cancer therapy due to its ability to modulate key molecular pathways involved in tumor progression and immune evasion. This review provides a comprehensive analysis of quercetin's effects on pathways such as PI3K/Akt/mTOR, MAPK/ERK, NF-κB, and JAK/STAT, which are central to cancer cell survival, proliferation, and apoptosis. Through inhibition of PI3K/Akt/mTOR and MAPK/ERK signaling, quercetin promotes apoptosis and reduces proliferation specifically in cancer cells while sparing healthy cells. Additionally, quercetin downregulates NF-κB activity and modulates JAK/STAT signaling, enhancing immune…

• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Awards: 2020/16573-3, 2023/01664-1
• CD
  Coordenação de Aperfeiçoamento de Pessoal de Nível Superior