Dual-Locked Fluorescence Probe for Monitoring the Dynamic Transition of Pulmonary Macrophages
Nanyang Technological University · Université Bourgogne Franche-Comté
Abstract
Pulmonary macrophages undergo dynamic changes in population, proportion, and polarization during respiratory diseases. Monitoring these changes is critical for understanding their roles in pathology, improving the diagnosis, and guiding drug development. However, current analytic methods based on tissue biopsy are invasive and static, limiting their ability to provide such dynamic information. Herein, we report a dual-locked macrophage-specific renal-clearable probe (DMRPNOCas) for the dynamic monitoring of pulmonary macrophages during influenza A virus (IAV) infection. DMRPNOCas activates fluorescence in the presence of two biomarkers (caspase-1 and NO) only coexpressed by M1 macrophages. To optimize the NO…
Citation impact
- FWCI
- 50.12
- Percentile
- 100%
- References
- 46
Authors
4- YHYuxuan Hu
Nanyang Technological University, Université Bourgogne Franche-Comté
- JLJing Liu
Nanyang Technological University, Université Bourgogne Franche-Comté
- MXMengke Xu
Nanyang Technological University, Université Bourgogne Franche-Comté
- KPKanyi PuCorresponding
Nanyang Technological University, Université Bourgogne Franche-Comté
Topics & keywords
- Chemistry
- Fluorescence
- Dual (grammatical number)
- Biophysics
- Nanotechnology
- Optics