articleNature Mental HealthFeb 13, 2025HYBRID OA

An analysis on the role of glucagon-like peptide-1 receptor agonists in cognitive and mental health disorders

Oxford Health NHS Foundation Trust · Warneford Hospital · +8 more institutions

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Abstract

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel drugs approved for diabetes and obesity. They are acknowledged as a major scientific breakthrough. In addition to their metabolic effects, these medications act on other bodily systems involved in the physiopathology of various neurological and psychiatric disorders. Several stakeholders are calling for more research to investigate the repurposing potential of GLP-1RAs in cognitive and mental disorders, while others advocate for a better assessment of their safety profile from a neuropsychiatric perspective. In this Analysis, we searched for relevant literature on the effects of GLP-1RAs across a range of illnesses, gathering and…

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