Glucose‐Activated Programmed Hydrogel with Self‐Switchable Enzyme‐Like Activity for Infected Diabetic Wound Self‐Adaptive Treatment

Abstract The defective blood glucose regulation ability of diabetic patients leading to bacterial infection, cellular oxidative stress, and vascular damage results in delayed healing of chronic diabetic wounds. Here, a glucose‐activated self‐switching enzyme‐like activity programmed hydrogel is proposed to provide self‐regulated timely intelligent insulin release affected by blood glucose fluctuations, thereby forming feedback blood glucose management and exerting a full‐stage wound healing. The hydrogel is composed of Au─MoS 2 ─phenylboronic acid nanozyme and insulin‐loaded nitroimidazole‐modified sodium alginate hypoxia‐sensitive microcapsules and penylboronic‐acid‐modified chitosan. It utilizes glucose as a…

• NN
  National Natural Science Foundation of China

  Award: 52273149
• FR
  Fundamental Research Funds for the Central Universities