Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy
Hunan University · Second Hospital of Shandong University · +6 more institutions
Abstract
Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, its clinical application in oncology is currently limited by issues such as suboptimal efficacy and potential off-target effects. The advent of nanotechnology has provided a new way for overcoming these challenges through the development of activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed to improve the specificity and efficacy of ferroptosis induction. This Review delves into the chemical and biological principles guiding the design of MNPs…
Citation impact
- FWCI
- 35.56
- Percentile
- 100%
- References
- 522
Authors
7- WXWei Xu
Hunan University, Second Hospital of Shandong University, Chemo (France), State Key Laboratory of Chemobiosensing and Chemometrics
- GGGuoqiang Guan
Hunan University, Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Chemo (France), State Key Laboratory of Chemobiosensing and Chemometrics
- RYRenye Yue
Hunan University, Anhui Medical University, Chemo (France), State Key Laboratory of Chemobiosensing and Chemometrics
- ZDZhe Dong
Hunan University, Chemo (France), State Key Laboratory of Chemobiosensing and Chemometrics
- LLLingling Lei
Hunan University, Guizhou University, Chemo (France), State Key Laboratory of Chemobiosensing and Chemometrics
Topics & keywords
- Chemistry
- Nanomaterials
- Cancer therapy
- Nanotechnology
- Cancer
- Internal medicine
Funding
- NNNational Natural Science Foundation of ChinaAwards: U21A20287, 22234003
- KUKorea University
- NRNational Research Foundation of KoreaAward: RS-2023-00208427
- NSNatural Science Foundation of Shandong ProvinceAward: ZR202103030844
- NKNational Key Research and Development Program of ChinaAward: 2019YFA0210103