articleJournal of the American Chemical SocietyFeb 15, 2025HYBRID OA

Ruthenium(II) Polypyridyl Complexes Containing COUBPY Ligands as Potent Photosensitizers for the Efficient Phototherapy of Hypoxic Tumors

DADiego Abad-MonteroAGAlbert GandiosoEIE. IzquierdoSCSergi ChumillasARAnna Rovira

Institut de Biomedicina de la Universitat de Barcelona · Universitat de Barcelona · +9 more institutions

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Abstract

Hypoxia, a hallmark of many solid tumors, is linked to increased cancer aggressiveness, metastasis, and resistance to conventional therapies, leading to poor patient outcomes. This challenges the efficiency of photodynamic therapy (PDT), which relies on the generation of cytotoxic reactive oxygen species (ROS) through the irradiation of a photosensitizer (PS), a process partially dependent on oxygen levels. In this work, we introduce a novel family of potent PSs based on ruthenium(II) polypyridyl complexes with 2,2′-bipyridyl ligands derived from COUPY coumarins, termed COUBPYs. Ru-COUBPY complexes exhibit outstanding in vitro cytotoxicity against CT-26 cancer cells when irradiated with light within the…

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50
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18

Topics & keywords

Topics
Keywords
  • Chemistry
  • Ruthenium
  • Combinatorial chemistry
  • Photochemistry
  • Organic chemistry
  • Catalysis
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