Bioactive nanomotor enabling efficient intestinal barrier penetration for colorectal cancer therapy

Oral drug delivery systems had natural potential for colorectal cancer drug therapy. While the drug delivery efficiency is severely hindered by the complex intestinal barriers, especially mucus and epithelium barriers, resulting in unsatisfactory therapeutic effects and limited clinical translation. In this work, a bioactive self-thermophoretic and gas dual-driven nanomotor is developed for colorectal cancer therapy through efficient intestinal mucus and epithelial barrier penetration. The nanomotor shows intestinal mucus barrier penetration and the paracellular pathway reversibly opening properties of intestinal epithelium barrier, increasing the delivery efficiency of cisplatin by 3.5 folds. Owing to the…

• NN
  National Natural Science Foundation of China

  Awards: 82222067, 82102936, 82473863
• CP
  China Postdoctoral Science Foundation

  Awards: 2023M743232, GZB20230676
• ZU
  Zhengzhou University