reviewJournal of the American Chemical SocietyFeb 17, 2025GREEN OA

The Role of Interfaces and Charge for Chemical Reactivity in Microdroplets

Lawrence Berkeley National Laboratory · University of California, Berkeley

PubMed
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Abstract

A wide variety of reactions are reported to be dramatically accelerated in aqueous microdroplets, making them a promising platform for environmentally clean chemical synthesis. However, to fully utilize the microdroplets for accelerating chemical reactions requires a fundamental understanding of how microdroplet chemistry differs from that of a homogeneous phase. Here we provide our perspective on recent progress to this end, both experimentally and theoretically. We begin by reviewing the many ways in which microdroplets can be prepared, creating water/hydrophobic interfaces that have been frequently implicated in microdroplet reactivity due to preferential surface adsorption of solutes, persistent electric…

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