Anti-Inflammatory Effects of SGLT2 Inhibitors: Focus on Macrophages
Institute of Cytology and Genetics · Siberian Branch of the Russian Academy of Sciences · +5 more institutions
Abstract
A growing body of evidence indicates that nonglycemic effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors play an important role in the protective effects of these drugs in diabetes, chronic kidney disease, and heart failure. In recent years, the anti-inflammatory potential of SGLT2 inhibitors has been actively studied. This review summarizes results of clinical and experimental studies on the anti-inflammatory activity of SGLT2 inhibitors, with a special focus on their effects on macrophages, key drivers of metabolic inflammation. In patients with type 2 diabetes, therapy with SGLT2 inhibitors reduces levels of inflammatory mediators. In diabetic and non-diabetic animal models, SGLT2 inhibitors…
Citation impact
- FWCI
- 47.27
- Percentile
- 100%
- References
- 163
Authors
6- EYElena Y. Rykova
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
- VVVadim V. Klimontov
Russian Academy of Sciences, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Institute of Clinical and Experimental Lymphology
- EKElena Kazakova
National Research Tomsk State University, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
- AIAnton I. Korbut
Russian Academy of Sciences, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Institute of Clinical and Experimental Lymphology
- TMTatyana Merkulova‐Rainon
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Topics & keywords
- Inflammation
- Anti-inflammatory
- Macrophage
- Chemistry
- Focus (optics)
- Inflammatory response
- Pharmacology
- Immunology
- Good health and well-being