reviewJournal of Biomedical ScienceFeb 19, 2025DIAMOND OA

EGF receptor in organ development, tissue homeostasis and regeneration

CTClaudia TitoSMSilvia MasciarelliGCGianni ColottiFFFrancesco Fazi

Sapienza University of Rome · Institute of Molecular Biology and Pathology · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cells, bone cells, blood and immune cells, heart cells, glia and stem neural cells. It belongs to the ErbB family, which includes three other related proteins: HER2/ErbB2/c-neu, HER3/ErbB3, and HER4/ErbB4. EGFR binds to seven known signaling molecules, including epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α). This binding triggers the formation of receptor pairs (dimers), self-phosphorylation of EGFR, and the activation of several signaling pathways within the cell. These pathways influence various cellular processes like proliferation, differentiation, migration,…

Citation impact

85
total citations
FWCI
82.88
Percentile
100%
References
257
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Cell biology
  • Biology
  • Epidermal growth factor receptor
  • Epidermal growth factor
  • ERBB3
  • Stromal cell
  • Signal transduction
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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