Plasma proteome variation and its genetic determinants in children and adolescents
University of Copenhagen · Novo Nordisk (Denmark) · +9 more institutions
Abstract
Our current understanding of the determinants of plasma proteome variation during pediatric development remains incomplete. Here, we show that genetic variants, age, sex and body mass index significantly influence this variation. Using a streamlined and highly quantitative mass spectrometry-based proteomics workflow, we analyzed plasma from 2,147 children and adolescents, identifying 1,216 proteins after quality control. Notably, the levels of 70% of these were associated with at least one of the aforementioned factors, with protein levels also being predictive. Quantitative trait loci (QTLs) regulated at least one-third of the proteins; between a few percent and up to 30-fold. Together with excellent…
Citation impact
- FWCI
- 59.11
- Percentile
- 100%
- References
- 107
Authors
15- LNLili Niu
University of Copenhagen, Novo Nordisk (Denmark), Novo Nordisk Foundation, Max Planck Institute of Biochemistry
- SSSara Stinson
University of Copenhagen, Novo Nordisk Foundation
- LALouise Aas Holm
University of Copenhagen, Novo Nordisk Foundation, Copenhagen University Hospital, Holbæk Sygehus
- MAMorten Asp Vonsild Lund
University of Copenhagen, Copenhagen University Hospital, Holbæk Sygehus
- CECilius Esmann Fonvig
University of Copenhagen, Novo Nordisk Foundation, Copenhagen University Hospital, Holbæk Sygehus
Topics & keywords
- Biology
- Variation (astronomy)
- Proteome
- Genetic variation
- Genetics
- Evolutionary biology
- Computational biology
- Gene
- Good health and well-being