Integrating the environmental and genetic architectures of aging and mortality

Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. To systematically identify environmental exposures associated with aging in the UK Biobank, we first conducted an exposome-wide analysis of all-cause mortality (n = 492,567) and then assessed the associations of these exposures with a proteomic age clock (n = 45,441), identifying 25 independent exposures associated with mortality and proteomic aging. These exposures were also associated with incident age-related multimorbidity, aging biomarkers and major disease risk…

• WT
  Wellcome Trust

  Awards: 203141/Z/16/Z, 223100/Z/21/Z, 203141
• UR
  UK Research and Innovation
• NI
  National Institute for Health and Care Research

  Award: 203141/Z/16/Z
• BH
  British Heart Foundation

  Award: RE/18/3/34214
• DO
  Department of Health and Social Care
• EC
  European Commission

  Award: 667375
• Z
  ZonMw

  Award: 733050814
• NN
  Novo Nordisk
• SR
  Swiss Re