Dual‐Gradient Silk‐Based Hydrogel for Spatially Targeted Delivery and Osteochondral Regeneration
Tufts University · Beijing University of Chemical Technology · +3 more institutions
Abstract
Contemporary clinical interventions for cartilage injuries focus on symptom management through pharmaceuticals and surgical procedures. Recent research has aimed at developing innovative scaffolds with biochemical elements, yet challenges like inadequate targeted delivery and reduced load-bearing capacity hinder their adoption. Inspired by the spatial gradients of biophysical and biochemical cues in native osteochondral tissues, a silk-based hydrogel that facilitates spontaneous dual-gradient formation, including mechanical gradients and growth factor gradients, for tissue regeneration, is presented. Driven by an electrical field, the hydrogel transitions from stiff to soft along the anode-to-cathode…
Citation impact
- FWCI
- 22.07
- Percentile
- 100%
- References
- 58
Authors
9Topics & keywords
- Materials science
- Regeneration (biology)
- Self-healing hydrogels
- Biomedical engineering
- Tissue engineering
- Nanotechnology
- SILK
- Dual (grammatical number)