articleJournal of the American Chemical SocietyFeb 20, 2025HYBRID OA

Pyridinium Rotor Strategy toward a Robust Photothermal Agent for STING Activation and Multimodal Image-Guided Immunotherapy for Triple-Negative Breast Cancer

SNShipeng NingPSPing ShangguanXZXinyan ZhuXOXinwen OuKWKaiyuan Wang

Guangxi Medical University · Institute of Cancer Research · +10 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

The immunosuppressive tumor microenvironment in triple-negative breast cancer could hinder the response to thorough immunotherapy and diminish the antitumor efficacy. Although the STING pathway emerges as a promising target to remedy defects, uncertain drug delivery might lead to off-target inflammatory reactions. Here, we manifest a novel phototheranostic agent with an aggregation-induced emission property that guided the pharmacological activation of a STING agonist for photothermal immunotherapy to create an immunologically "hot" tumor. A pyridinium rotor strategy is proposed to develop a positively charged TBTP-Bz, which is stably coincorporated with a STING agonist MSA-2 into thermal-responsive…

Citation impact

65
total citations
FWCI
33.99
Percentile
100%
References
45
Citations per year

Authors

12

Topics & keywords

Topics
Keywords
  • Sting
  • Cancer research
  • Photothermal therapy
  • Immunotherapy
  • Chemistry
  • Cancer immunotherapy
  • Abscopal effect
  • Breast cancer
UN Sustainable Development Goals
  • Good health and well-being
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