reviewJournal of Ovarian ResearchFeb 20, 2025GOLD OA

Physiopathology of polycystic ovary syndrome in endocrinology, metabolism and inflammation

Zhejiang Chinese Medical University · Wenzhou Medical University · +2 more institutions

PubMed
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Abstract

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by elevated androgen levels, ovarian cysts, and impaired ovulation in females. This condition is closely linked with various reproductive health issues and has significant impacts on endocrine and metabolic pathways. Patients with PCOS commonly exhibit hyperandrogenaemia and insulin resistance, leading to complications such as acne, hirsutism, weight fluctuations, and metabolic disturbances, as well as an increased risk for type 2 diabetes, cardiovascular disease, and endometrial cancer. Although extensive research has identified several mechanistic aspects of PCOS, a thorough understanding of its pathophysiology remains…

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