Coordination Engineering in Fe‐Mn Dual‐Atom Nanozyme: Yielding ROS Storm to Efficiently Promote Wound Healing

Abstract Multidrug‐resistant bacterial infections have become a global public health issue. To solve this dilemma, single‐atom nanozymes have been used as versatile antibiotics. However, the efficacy of individual nanozyme is hindered by their limited catalytic activity and antibacterial effect. Herein, a novel N 3 ‐Fe 1 ‐Mn 1 ‐N 2 S nanozyme (Fe/Mn‐SNC), with neighboring Mn and Fe dual single‐atom pairs decorated on yolk‐shell‐like carbon skeleton, is constructed through partial modulation of Fe‐Mn dual site coordination by sulfur atoms. The developed Fe/Mn‐SNC possesses superior multienzyme‐like cascade activities (oxidase‐, superoxide‐, and peroxidase‐like activities). It catalyzes the conversion of O 2…