High‐Strength Gelatin Hydrogel Scaffold with Drug Loading Remodels the Inflammatory Microenvironment to Enhance Osteoporotic Bone Repair

Osteoporosis is a widespread condition that induces an inflammatory microenvironment, limiting the effectiveness of conventional therapies and presenting significant challenges for bone defect repair. To address these issues, a high-strength gelatin hydrogel scaffold loaded with roxadustat is developed, specifically designed to remodel the inflammatory microenvironment and enhance osteoporotic bone regeneration. By incorporating minimal methacrylated hyaluronic acid (HAMA) into an o-nitrobenzyl functionalized gelatin (GelNB) matrix, a gelatin hydrogel with a fracture strength of 10 MPa is achieved, providing exceptional structural stability and enabling precise scaffold fabrication through digital light…

• NN
  National Natural Science Foundation of China

  Awards: 52103119, 32071344, 32121005, 22475129, U23A20692
• NK
  National Key Research and Development Program of China

  Award: 2022YFC2403004