Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces

Neural interface technologies are increasingly evolving towards bio-inspired approaches to enhance integration and long-term functionality. Recent strategies merge soft materials with tissue engineering to realize biologically-active and/or cell-containing living layers at the tissue-device interface that enable seamless biointegration and novel cell-mediated therapeutic opportunities. This review maps the field of bio-inspired electronics and discusses key recent developments in tissue-like and regenerative bioelectronics, from soft biomaterials and surface-functionalized bioactive coatings to cell-containing 'biohybrid' and 'all-living' interfaces. We define and contextualize key terminology in this emerging…

• NS
  National Science Foundation

  Awards: CAREER Award 2339748, CAREER, 2339748
• UD
  U.S. Department of Veterans Affairs
• AS
  Alexander S. Onassis Public Benefit Foundation

  Award: F ZΤ 011-1/2023-2024
• NI
  National Institutes of Health

  Awards: R01-NS127895, R01-NS117757
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: R01-NS127895, R01-NS117757