reviewLipids in Health and DiseaseFeb 21, 2025GOLD OA

Lipids dysregulation in diseases: core concepts, targets and treatment strategies

Mohanlal Sukhadia University · Affiliated Hospital of Taishan Medical University · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid metabolism is associated with various conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. This review explores the mechanisms underlying lipid metabolism, emphasizing the roles of key lipid species such as triglycerides, phospholipids, sphingolipids, and sterols in cellular physiology and pathophysiology. It also examines the genetic and environmental factors contributing to lipid dysregulation and the challenges of diagnosing and managing lipid-related disorders. Recent advancements in lipid-lowering therapies, including PCSK9…

Citation impact

58
total citations
FWCI
87.72
Percentile
100%
References
169
Citations per year

Authors

7

Topics & keywords

Keywords
  • Lipidomics
  • Lipid metabolism
  • Ezetimibe
  • Lipidome
  • Clinical nutrition
  • Lipid Metabolism Disorder
  • Sphingolipid
  • Biology
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