Global burden of chronic kidney disease due to diabetes mellitus, 1990-2021, and projections to 2050

Chronic kidney disease (CKD) is a serious complication of diabetes, and the global burden of the disease is gradually increasing.

This study systematically analyzed the trends and future projections of the worldwide burden of chronic kidney disease caused by type 1 and type 2 diabetes mellitus based on the Global Burden of Disease Study (GBD) using data from 1990 to 2021. Number of deaths, Age-standardized mortality rates, disability-adjusted life years (DALYs), and age-standardized DALYs rate were used to estimate the disease burden. The study used Estimated Annual Percentage Changes (EAPCs) to calculate trends in the burden of each disease subtype and different regions and assessed the impact of various age groups and metabolic factors on chronic kidney disease due to diabetes. The ARIMA model was further used to predict the burden of Diabetic nephropathy from 2022 to 2050.