Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis
Xiamen University · First Affiliated Hospital of Xiamen University · +3 more institutions
Abstract
Alzheimer's disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows peripheral immune cells to infiltrate the central nervous system (CNS), worsening neuroinflammation and disease progression. We examine recent findings on interactions between peripheral immune cells and CNS-resident microglia, forming a self-perpetuating inflammatory cycle leading to neuronal dysfunction. Moreover, this review emphasizes recent developments in the dysregulation of immune factors from both the periphery and CNS, and their impact on AD progression. With ongoing…
Citation impact
- FWCI
- 31.48
- Percentile
- 100%
- References
- 149
Authors
6- SZShuo ZhangCorresponding
Xiamen University, First Affiliated Hospital of Xiamen University
- YGYue Gao
Xiamen University, First Affiliated Hospital of Xiamen University
- YZYini Zhao
Xiamen University, First Affiliated Hospital of Xiamen University
- TYTimothy Y. Huang
Sanford Burnham Prebys Medical Discovery Institute, Discovery Institute
- QZQiuyang Zheng
Shenzhen University, Xiamen University, First Affiliated Hospital of Xiamen University
Topics & keywords
- Neuroinflammation
- Immune system
- Microglia
- Neuroscience
- Pathogenesis
- Disease
- Medicine
- Central nervous system
Funding
- NNNational Natural Science Foundation of ChinaAwards: 202401, 82325018 and U21A20358 to X.W., 2021YFA1101401, 82271451, STI2030, 82401678, 82301358, U21A20358, 82325018
- NSNatural Science Foundation of Fujian ProvinceAward: 2021J02004
- BABasic and Applied Basic Research Foundation of Guangdong ProvinceAward: 2021B1515120081