A Comprehensive Review of Nanoparticle-Based Drug Delivery for Modulating PI3K/AKT/mTOR-Mediated Autophagy in Cancer
Wayne State University · The Barbara Ann Karmanos Cancer Institute · +3 more institutions
Abstract
The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) pathway plays a crucial role in the regulation of autophagy, a cellular mechanism vital for homeostasis through the degradation of damaged organelles and proteins. The dysregulation of this pathway is significantly associated with cancer progression, metastasis, and resistance to therapy. Targeting the PI3K/AKT/mTOR signaling pathway presents a promising strategy for cancer treatment; however, traditional therapeutics frequently encounter issues related to nonspecific distribution and systemic toxicity. Nanoparticle-based drug delivery systems represent a significant advancement in addressing these limitations. Nanoparticles…
Citation impact
- FWCI
- 44.38
- Percentile
- 100%
- References
- 79
Authors
5- MAMd. Ataur RahmanCorresponding
Wayne State University, The Barbara Ann Karmanos Cancer Institute
- MJMaroua Jalouli
Imam Mohammad ibn Saud Islamic University
- SKSujay Kumar Bhajan
Gopalganj Science and Technology University
- MAMohammed Al‐Zharani
Imam Mohammad ibn Saud Islamic University
- AHAbdel Halim Harrath
King Saud University
Topics & keywords
- PI3K/AKT/mTOR pathway
- Autophagy
- Nanocarriers
- Protein kinase B
- Drug delivery
- Cancer research
- Pharmacology
- Medicine
- Good health and well-being