Engineering nanozyme immunomodulator with magnetic targeting effect for cascade-enzyodynamic and ultrasound-reinforced metallo-immunotherapy in prostate carcinoma
Shandong University · Kementerian Pendidikan Malaysia · +3 more institutions
Abstract
Conventional immunotherapy exhibits low response rates due to the immunosuppressive tumor microenvironment (TME). To overcome this limitation, this study introduces ZFPG nanoparticles (ZFPG NPs) with ZnFe2O4@Pt cores and glucose oxidase (GOx) shells. The ZFPG NPs possess five-enzyme activities, good sonosensitivity, and remarkable magnetic targeting properties, which facilitate sono-metallo-immunotherapy for prostate cancer treatment in male mice. Specifically, the magnetic targeting ability effectively improves their accumulation in tumors while still showing enrichment in the liver and kidneys. The multienzyme cascade catalysis and sonosensitivity of these NPs effectively deplete glutathione and glucose, and…
Citation impact
- FWCI
- 27.72
- Percentile
- 100%
- References
- 38
Authors
8- YWYandong WangCorresponding
Shandong University, Kementerian Pendidikan Malaysia
- HLHaodong Li
Shandong University, Shandong Provincial Hospital, Kementerian Pendidikan Malaysia
- JLJuntang Lin
Shandong Provincial Hospital, Shandong First Medical University
- YLYutang Li
Shandong University, Kementerian Pendidikan Malaysia
- KZKeqin Zhang
Shandong Provincial Hospital, Shandong First Medical University
Topics & keywords
- Prostate carcinoma
- Immunotherapy
- Cancer research
- Cascade
- Medicine
- Prostate cancer
- Oncology
- Immunology