articleCancer ResearchFeb 24, 2025HYBRID OA

Intratumoral Fusobacterium nucleatum Recruits Tumor-Associated Neutrophils to Promote Gastric Cancer Progression and Immune Evasion

TZTianhao ZhangYLYing LiEZErtao ZhaiRZRisheng ZhaoYQYan Qian

Sun Yat-sen University · The First Affiliated Hospital, Sun Yat-sen University · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Intratumoral microbiota can affect the development and progression of many types of cancer, including gastric cancer. A better understanding of the precise mechanisms by which microbiota support gastric cancer could lead to improved therapeutic approaches. In this study, we investigated the effect of intratumoral microbiota on the tumor immune microenvironment during gastric cancer malignant progression. Analysis of human gastric cancer tissues with 16S rRNA amplicon sequencing revealed that Fusobacterium nucleatum was significantly enriched in gastric cancer tissues with lymph node metastasis and correlated with a poor prognosis. F. nucleatum infection spontaneously induced chronic gastritis and promoted…

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71
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43.30
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100%
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61
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Authors

18

Topics & keywords

Topics
Keywords
  • Fusobacterium nucleatum
  • Immune system
  • Cancer research
  • Cancer
  • Tumor progression
  • Tumor microenvironment
  • Immunology
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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