reviewJournal of NanobiotechnologyFeb 25, 2025GOLD OA

Emerging strategies against accelerated blood clearance phenomenon of nanocarrier drug delivery systems

JPJianquan PanYWYanyan WangYCYunna ChenCZCheng ZhangHDHui Deng

Anhui University of Traditional Chinese Medicine

PubMed
Indexed incrossrefdoajpubmed

Abstract

Nanocarrier drug delivery systems (NDDS) have gained momentum in the field of anticancer or nucleic acid drug delivery due to their capacity to aggrandize the targeting efficacy and therapeutic outcomes of encapsulated drugs. A disadvantage of NDDS is that repeated administrations often encounter an obstacle known as the "accelerated blood clearance (ABC) phenomenon". This phenomenon results in the rapid clearance of the secondary dose from the bloodstream and markedly augmented liver accumulation, which substantially undermines the accurate delivery of drugs and the therapeutic effect of NDDS. Nevertheless, the underlying mechanism of this phenomenon has not been elucidated and there is currently no effective…

Citation impact

55
total citations
FWCI
25.28
Percentile
100%
References
158
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • Nanocarriers
  • Drug delivery
  • Mechanism (biology)
  • Drug
  • Pharmacology
  • Phenomenon
  • Nanotechnology
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding