Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing
University of Jinan · Shandong Tumor Hospital · +1 more institution
Abstract
Abstract The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory and proliferative phases. A near‐infrared (NIR)‐activated inverse oxide/alloy‐structured nanozyme (Co 7 Fe 3 /ZnO@C) is developed, featuring enzymatic cascade activities to tune ROS homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), and photothermal (PTT) therapies. The nanozyme orchestrates a self‐regulated cascade: peroxidase (POD)‐like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot…
Citation impact
- FWCI
- 30.26
- Percentile
- 100%
- References
- 47
Authors
11Topics & keywords
- Reactive oxygen species
- Catalase
- Hydroxyl radical
- Superoxide dismutase
- Antioxidant
- Wound healing
- Radical
- Chemistry