articleAnnals of the New York Academy of SciencesFeb 25, 2025BRONZE OA

Short‐chain fatty acids mediate gut microbiota–brain communication and protect the blood–brain barrier integrity

MCMei ChenghanWLWanxin LiBZBangcheng ZhaoYHYao HeQLQinxi Li

Sichuan University · West China Hospital of Sichuan University · +5 more institutions

PubMed
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Abstract

The human gut, with a complex community of microbes, is essential for maintaining overall health. This gut microbiota engages in two-way communication with the central nervous system, collectively known as the gut microbiota-brain axis. Alterations in gut microbiota have been associated with various neurological disorders, and disruptions to the blood-brain barrier (BBB) may be crucial, though the exact mechanisms remain unknown. In the current study, we investigated the impacts of short-chain fatty acids (SCFAs) on the integrity of the BBB, which was compromised by orally administered antibiotics in rhesus monkeys and C57BL/6n mice. Our results showed that SCFA supplementation notably enhanced BBB integrity…

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43
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100%
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10

Topics & keywords

Topics
Keywords
  • Butyrate
  • Gut flora
  • Dysbiosis
  • Blood–brain barrier
  • Gut–brain axis
  • Propionate
  • Tight junction
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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