Amyloid‐Templated Ceria Nanozyme Reinforced Microneedle for Diabetic Wound Treatments

Abstract Amyloid fibrils have emerged as excellent templates and building blocks for the development of ordered functional materials with considerable potential in biomedical applications. Here, lysozyme amyloid fibrils (Lys‐AFs) are employed as templates for the in situ synthesis of ceria nanozymes (Lys‐AFs‐Ceria) with ultrafine dimensions, an optimized Ce 3+ /Ce 4+ ratio, and uniform distribution on the fibril surface, addressing the challenges of low catalytic efficiency and high susceptibility to aggregation typical of traditional methods. As a proof of concept, it is further applied Lys‐AFs‐Ceria to develop hydrogel/microneedle for treating bacteria‐infected diabetic wounds via non‐covalent interactions…

• NS
  Natural Science Foundation of Shanghai

  Award: 22ZR1415400
• NN
  National Natural Science Foundation of China

  Awards: 42125706, 42407582, 42477424
• CP
  China Postdoctoral Science Foundation

  Award: 2024M761917
• CS
  China Scholarship Council

  Award: 202206740021
• SR
  Shanghai Rising-Star Program

  Awards: 24YF2712200, 23QC1400500