reviewJournal of NanobiotechnologyFeb 26, 2025GOLD OA

The blood–brain barriers: novel nanocarriers for central nervous system diseases

JLJiajun LiuTWTing WangJDJianwei DongYLYuan Lü

Tianjin University of Science and Technology · Tsinghua University

PubMed
Indexed incrossrefdoajpubmed

Abstract

The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood-brain barrier (BBB) often prevents drugs intended for CNS diseases from effectively crossing into the brain parenchyma to deliver their therapeutic effects. The blood-brain barrier is a semi-permeable barrier with high selectivity. The BBB primarily manages the transport of substances between the blood and the CNS. To enhance drug delivery for CNS disease treatment, various brain-based drug delivery strategies overcoming the BBB have been developed. Among them, nanoparticles (NPs) have been emphasized due to their multiple excellent properties. This review starts with an overview of the BBB's…

Citation impact

68
total citations
FWCI
31.26
Percentile
100%
References
217
Citations per year

Authors

4

Topics & keywords

Topics
Keywords
  • Nanocarriers
  • Blood–brain barrier
  • Central nervous system
  • Drug delivery
  • Neuroscience
  • Brain disease
  • Drug
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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