Epigenetic drugs in cancer therapy
Queensland University of Technology · Princess Alexandra Hospital
Abstract
Genetic and epigenetic modifications of DNA are involved in cancer initiation and progression. Epigenetic modifications change chromatin structure and DNA accessibility and thus affect DNA replication, DNA repair and transcription. Epigenetic modifications are reversible and include DNA methylation, histone acetylation and histone methylation. DNA methylation is catalysed by DNA methyltransferases, histone acetylation and deacetylation are catalysed by histone acetylases and deacetylases, while histone methylation is catalysed by histone methyltransferases. Epigenetic modifications are dysregulated in several cancers, making them cancer therapeutic targets. Epigenetic drugs (epi-drugs) which are inhibitors of…
Citation impact
- FWCI
- 41.90
- Percentile
- 100%
- References
- 158
Authors
3Topics & keywords
- Cancer epigenetics
- Epigenetics
- Epigenetic therapy
- Histone deacetylase
- Biology
- Histone
- Methyltransferase
- DNA methylation
- Good health and well-being