articleAccounts of Chemical ResearchFeb 26, 2025Closed access

Cobalt(III)-Catalyzed Enantioselective C–H Functionalization: Ligand Innovation and Reaction Development

QYQi‐Jun YaoBSBing‐Feng Shi

Zhejiang University

PubMed
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Abstract

ConspectusIn contrast to precious transition metals, such as palladium and rhodium, the development of novel chiral ligands for enantioselective C–H functionalizations catalyzed by earth-abundant, cost-effective, and environmentally friendly 3d metals poses substantial challenges, primarily due to the variable oxidation states, intricate coordination patterns, and limited mechanistic insights. In this Account, we summarize our research endeavors in the development of three novel types of Co(III) catalysis: pseudotetrahedral achiral Cp*Co(III)/chiral carbonyl acid (CCA) catalysis, in situ-generated chiral octahedral cobalt(III) via cobalt/salicyloxazoline (Salox) catalysis, and Co(II)/chiral phosphoric acid…

Citation impact

66
total citations
FWCI
49.75
Percentile
100%
References
78
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Authors

2

Topics & keywords

Topics
Keywords
  • Enantioselective synthesis
  • Surface modification
  • Cobalt
  • Catalysis
  • Ligand (biochemistry)
  • Chemistry
  • Combinatorial chemistry
  • Organic chemistry
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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