Investigating the stability of RNA-lipid nanoparticles in biological fluids: Unveiling its crucial role for understanding LNP performance
Centre for Human Drug Research · Johannes Gutenberg University Mainz · +1 more institution
Abstract
Lipid nanoparticles (LNPs) are the most established and clinically advanced platform for RNA delivery. While significant efforts have been made to improve RNA delivery efficiency for improved protein production, the interplay between physiological stability, target specificity, and therapeutic efficacy of RNA-LNPs remains largely unexplored. This review highlights the crucial, yet often overlooked, impact of in vivo stability or instability of RNA-LNPs in contact with biological fluids on delivery performance. We discuss the various factors, including lipid composition, particle surface properties and interactions with proteins in physiological conditions, and provide an overview of the current methods for…
Citation impact
- FWCI
- 30.20
- Percentile
- 100%
- References
- 193
Authors
2Topics & keywords
- Chemistry
- Biological fluids
- Nanoparticle
- Nanotechnology
- Chromatography
- Materials science