GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

Dand, Nick; Stuart, Philip E.; Bowes, John; Ellinghaus, David; Nititham, Joanne; Saklatvala, Jake; Teder‐Laving, Maris; Thomas, Laurent F.; Traks, Tanel; Uebe, Steffen; Aßmann, G.; Baudry, David; Behrens, Frank; Billi, Allison C.; Brown, Matthew A.; Burkhardt, Harald; Capon, Francesca; Chung, Raymond T.; Curtis, Charles; Duckworth, Michael; Ellinghaus, Eva; FitzGerald, Oliver; Gerdes, Sascha; Griffiths, C.E.M.; Gulliver, Susanne; Helliwell, Philip; Ho, Pauline; Hoffmann, Per; Holmen, Oddgeir L.; Huang, Zhiming; Hveem, Kristian; Jadon, Deepak R.; Köhm, Michaela; Kraus, Cornelia; Lamacchia, Céline; Lee, Sang Hyuck; Ma, Feiyang; Mahil, Satveer K.; McHugh, Neil; McManus, Ross; Modalsli, Ellen Heilmann; Nissen, Michael J.; Nöthen, Markus M.; Oji, Vinzenz; Oksenberg, Jorge R.; Patrick, Matthew T.; White, Bethany E. Perez; Ramming, Andreas; Rech, Jürgen; Rosen, Cheryl F.; Sarkar, Mrinal K.; Schett, Georg; Schmidt, Börge; Tejasvi, Trilokraj; Traupe, Heiko; Voorhees, John J.; Wacker, Eike Matthias; Warren, Richard B.; Bogle, Rachael; Weidinger, Stephan; Wen, Xiaoquan; Zhang, Zhaolin; group, BSTOP study; Burden, A. David; Smith, Catherine; Brown, Sara; Dand, Nick; Mahil, Satveer K.; McAteer, Helen; Schofield, Julia; Siebert, Stefan; Metspalu, Andres; Milani, Lili; Nelis, Mari; Barton, Anne; Chandran, Vinod; Esko, Tõnu; Foerster, John; Franke, André; Gladman, Dafna D.; Guðjónsson, Jóhann E.; Gulliver, Wayne; Hüffmeier, Ulrike; Kingo, Külli; Kõks, Sulev; Liao, Wilson; Løset, Mari; Mägi, Reedik; Nair, Rajan P.; Rahman, Proton; Reis, André; Smith, Catherine; Meglio, Paola Di; Barker, Jonathan N.; Tsoi, Lam C.; Simpson, Michael A.; Elder, James T.

doi:10.1038/s41467-025-56719-8

reviewNature CommunicationsFeb 28, 2025GOLD OA

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets

NDNick Dand PEPhilip E. Stuart JBJohn Bowes DEDavid Ellinghaus JNJoanne Nititham

King's College London · Health Data Research UK · +57 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not fully explained by variation at robustly identified risk loci. To refine the genetic map of psoriasis susceptibility we meta-analysed 18 GWAS comprising 36,466 cases and 458,078 controls and identified 109 distinct psoriasis susceptibility loci, including 46 that have not been previously reported. These include susceptibility variants at loci in which the therapeutic targets IL17RA and AHR are encoded, and deleterious coding variants supporting potential new drug targets…

Citation impact

55

total citations

FWCI: 33.09
Percentile: 100%
References: 100

Citations per year

Authors

97

Topics & keywords

Topics

Keywords

Psoriasis
Genome-wide association study
Epigenetics
Biology
Transcriptome
Disease
Genetic predisposition
Genetics

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.