For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy
Kermanshah University of Medical Sciences · Shahid Chamran University of Ahvaz · +5 more institutions
Abstract
Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive and innovative perspective on how nanomedicine can modify the TME to enhance therapy. Strategies include using nanoparticles to improve oxygenation, adjust acidity, and alter the extracellular matrix, making treatments more effective. Additionally, nanoparticles can enhance immune responses by activating immune cells and reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy and radiotherapy, nanoparticles show promise in overcoming traditional treatment barriers. The review discusses how changes…
Citation impact
- FWCI
- 22.10
- Percentile
- 100%
- References
- 226
Authors
7- SKSoroush Karimi
Kermanshah University of Medical Sciences
- RBRoksana Bakhshali
Shahid Chamran University of Ahvaz, Islamic Azad University, Ahvaz Branch
- SBSoheil Bolandi
Shiraz University of Medical Sciences
- ZZZahra Zahed
Ardabil University of Medical Sciences
- SSSeyedeh Sahar Mojtaba Zadeh
Tehran University of Medical Sciences
Topics & keywords
- Tumor microenvironment
- Cancer therapy
- Cancer
- Cancer research
- Medicine
- Tumor cells
- Internal medicine