Exploring toxicological pathways of microplastics and nanoplastics: Insights from animal and cellular models

Microplastics (MPs) and nanoplastics (NPs) represent an emerging issue for human and animal health. This review critically examines in vitro and in vivo studies to elucidate their mechanisms of action and toxicological effects. Key objectives included: providing a comprehensive overview of MP-NPs studies in literature, assessing experimental conditions relative to real environmental scenarios, and identifying toxicological pathways at the molecular level. The findings revealed significant progress in understanding MP-NPs impacts. In particular, it has been observed the promotion of inflammation, oxidative stress, apoptosis, autophagy, and endoplasmic reticulum (ER) stress via specific signaling axes.…