reviewSignal Transduction and Targeted TherapyMar 5, 2025GOLD OA

Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines

University of Electronic Science and Technology of China · Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. The integration of novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering advancements, and artificial intelligence have significantly expedited the development of groundbreaking peptide-based drugs, effectively addressing the obstacles associated with their character, such as the rapid clearance and degradation, necessitating subcutaneous injection leading to increasing patient discomfort, and ultimately advancing translational research efforts. Peptides are presently employed in the management and diagnosis of a diverse array of medical…

Citation impact

267
total citations
FWCI
165.42
Percentile
100%
References
842
Citations per year

Authors

8

Topics & keywords

Keywords
  • Drug development
  • Drug
  • Drug delivery
  • Medicine
  • Peptide
  • Computational biology
  • Virology
  • Pharmacology
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