Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response
Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center
Abstract
Cancer-associated fibroblasts (CAF) play a crucial role in tumor progression and immune regulation. However, the functional heterogeneity of CAFs remains unclear. Here, we identify antigen-presenting CAFs (apCAF), characterized by high MHC II expression, in gastric cancer (GC) tumors and find that apCAFs are preferentially located near tertiary lymphoid structures. Both in vivo and in vitro experiments demonstrate that apCAFs promote T cell activation and enhances its cytotoxic and proliferative capacities, thereby strengthening T cell-mediated anti-tumor immunity. Additionally, apCAFs facilitate the polarization of macrophages toward a pro-inflammatory phenotype. These polarized macrophages, in turn, promote…
Citation impact
- FWCI
- 62.04
- Percentile
- 100%
- References
- 62
Authors
8- JSJunquan SongCorresponding
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- RWRongyuan Wei
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- CLChenchen Liu
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- ZZZhenxiong Zhao
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
- XLXuanjun Liu
Shanghai Medical College of Fudan University, Fudan University Shanghai Cancer Center
Topics & keywords
- Immunotherapy
- Cancer immunotherapy
- Immune system
- Immunity
- Cancer
- Tumor immunology
- Immunology
- Antigen