reviewSignal Transduction and Targeted TherapyMar 7, 2025GOLD OA

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

FGFan GuanRWRuixuan WangZYZhenjie YiPLPeng LuoWLWanyao Liu

Central South University · Xiangya Hospital Central South University · +8 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in immune defense, surveillance, and homeostasis. This review systematically discusses the types of hematopoietic progenitors that give rise to macrophages, including primitive hematopoietic progenitors, erythro-myeloid progenitors, and hematopoietic stem cells. These progenitors have distinct genetic backgrounds and developmental processes. Accordingly, macrophages exhibit complex and diverse functions in the body, including phagocytosis and clearance of cellular debris, antigen presentation, and immune response, regulation of inflammation and cytokine production, tissue remodeling and repair, and multi-level…

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236
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142.85
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100%
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1,224
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Authors

10

Topics & keywords

Topics
Keywords
  • Immune system
  • Haematopoiesis
  • Mononuclear phagocyte system
  • Biology
  • Macrophage
  • Progenitor cell
  • Immunology
  • Inflammation
UN Sustainable Development Goals
  • Good health and well-being
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