Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies

In recent years, the incidence of acute respiratory distress syndrome (ARDS) has been gradually increasing. Despite advances in supportive care, ARDS remains a significant cause of morbidity and mortality in critically ill patients. ARDS is characterized by acute hypoxaemic respiratory failure with diffuse pulmonary inflammation and bilateral edema due to excessive alveolocapillary permeability in patients with non-cardiogenic pulmonary diseases. Over the past seven decades, our understanding of the pathology and clinical characteristics of ARDS has evolved significantly, yet it remains an area of active research and discovery. ARDS is highly heterogeneous, including diverse pathological causes, clinical…

• NN
  National Natural Science Foundation of China

  Awards: 82272241, 82270392, 82241060
• CP
  China Postdoctoral Science Foundation

  Award: 2023M732462
• DO
  Department of Science and Technology of Sichuan Province

  Award: 2023ZYD0094
• NH
  National Health Commission of the People's Republic of China