Starfish-Inspired Synergistic Reinforced Hydrogel Wound Dressing: Dual Responsiveness and Enhanced Bioactive Compound Delivery for Advanced Skin Regeneration and Management

Effective wound management demands advanced dressings that protect while actively supporting healing. Traditional wound dressings often fall short of meeting the complex needs of skin repair. Inspired by the regenerative abilities of starfish, we developed a bionically engineered hydrogel designed to enhance wound healing. The hydrogel is synthesized through the coassembly of dopamine-modified cellulose nanofibers, chitosan, (3-aminobenzeneboronic acid)-grafted oxidized dextran, and poly(vinyl alcohol), utilizing dynamic Schiff base and boronic ester linkages. This innovative design imparts multifunctional properties, including injectability, 3D printability, antibacterial activity, self-adhesion,…

• CF
  Canada Foundation for Innovation

  Award: 38623
• NN
  National Natural Science Foundation of China

  Awards: 82470249, 51661033, 82270249, 22178233, 52061041, 31660538
• CE
  Canada Excellence Research Chairs, Government of Canada

  Award: CERC-2018-00006
• CP
  China Postdoctoral Science Foundation

  Award: 2022M722707
• SK
  State Key Laboratory of Polymer Materials Engineering

  Award: sklpme 2020-03-01
• NK
  National Key Research and Development Program of China

  Award: 2022YFA0912800
• HE
  H2020 European Research Council

  Award: 788489