Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease
Northwestern University · Agency for Science, Technology and Research · +5 more institutions
Abstract
Alzheimer's disease (AD) therapies utilizing amyloid-β (Aβ) immunization have shown potential in clinical trials. Yet, the mechanisms driving Aβ clearance in the immunized AD brain remain unclear. Here, we use spatial transcriptomics to explore the effects of both active and passive Aβ immunization in the AD brain. We compare actively immunized patients with AD with nonimmunized patients with AD and neurologically healthy controls, identifying distinct microglial states associated with Aβ clearance. Using high-resolution spatial transcriptomics alongside single-cell RNA sequencing, we delve deeper into the transcriptional pathways involved in Aβ removal after lecanemab treatment. We uncover spatially distinct…
Citation impact
- FWCI
- 59.27
- Percentile
- 100%
- References
- 60
Authors
23Topics & keywords
- Disease
- Amyloid (mycology)
- Amyloid β
- Medicine
- Alzheimer's disease
- Microglia
- Immunology
- Neuroscience