articleNature CommunicationsMar 7, 2025GOLD OA

Urinary extracellular vesicle N-glycomics identifies diagnostic glycosignatures for bladder cancer

YLYang LiBFBin FuMWMaoyu WangWCWeiyu ChenJFJiawei Fan

Fudan University · Shanghai First People's Hospital · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges. Urinary extracellular vesicles (EVs) are promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. This study pioneers urinary EV N-glycomics for bladder cancer diagnosis. We have generated a comprehensive N-glycome landscape of urinary EVs through high-throughput N-glycome analysis, identifying a total of 252 N-glycans from 333 individuals. In bladder cancer patients, urinary EVs exhibit decreased fucosylation and increased sialylation level. An Eight N-glycan diagnostic model demonstrates strong performance in both validation cohorts,…

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Authors

11

Topics & keywords

Topics
Keywords
  • Glycomics
  • Extracellular vesicles
  • Extracellular vesicle
  • Bladder cancer
  • Urinary system
  • Urinary bladder
  • Urinary Bladder Cancer
  • Medicine
UN Sustainable Development Goals
  • Zero hunger
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