Diversity-Generating Skeletal Editing Transformations

Synthesis for each new molecule. However, many skeletal editing transformations are inherently restricted to generating a single product from a single starting compound, limiting the potential for diversification, a concept central to expediting structure-activity relationship (SAR) investigations. In this Account, we describe our efforts to develop novel skeletal editing transformations in which a modification to the central motif of a molecule is performed simultaneously with the incorporation of additional functionality that can be easily varied through a judicious choice of the reagents. Specifically, we successfully developed an α-iodonium diazo-based carbynyl radical equivalent reagent that, under…

• AV
  Alexander von Humboldt-Stiftung