Electrochemical Biosensors for the Detection of Exosomal microRNA Biomarkers for Early Diagnosis of Neurodegenerative Diseases
Technion – Israel Institute of Technology · Guangdong Technion-Israel Institute of Technology · +6 more institutions
Abstract
Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) and Parkinson's (PD) is crucial for slowing their progression and enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to their ability to reflect the diseases' pathology, yet their low abundance poses significant detection hurdles. This review article delves into the burgeoning field of electrochemical biosensors, designed for the precise detection of exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining the sensitivity required to detect low-abundance biomarkers with the specificity needed to discern miRNA profiles distinctive to neural…
Citation impact
- FWCI
- 20.55
- Percentile
- 100%
- References
- 144
Authors
11- JYJiacheng Yu
Technion – Israel Institute of Technology, Guangdong Technion-Israel Institute of Technology
- RZRunzhi Zhou
Technion – Israel Institute of Technology, Guangdong Technion-Israel Institute of Technology
- SLShan Liu
University of Electronic Science and Technology of China, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- JZJintao Zheng
Technion – Israel Institute of Technology, Guangdong Technion-Israel Institute of Technology
- HYHaoyang Yan
Technion – Israel Institute of Technology, Guangdong Technion-Israel Institute of Technology
Topics & keywords
- Chemistry
- microRNA
- Biosensor
- Diagnostic biomarker
- Computational biology
- Nanotechnology
- Biomarker
- Biochemistry