A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX
University Hospital Schleswig-Holstein · University of Lübeck · +9 more institutions
Abstract
Randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy and safety of both pharmacological and non-pharmacological interventions. However, while they are designed to control confounders and ensure internal validity, their usually stringent inclusion and exclusion criteria often limit the generalizability of findings to broader patient populations. Moreover, RCTs are resource-intensive, frequently underpowered to detect rare adverse events, and sometimes narrowly focused due to their highly controlled environments. In contrast, real-world data (RWD), typically derived from electronic health records (EHRs) and claims databases, offers a valuable counterpart for answering research…
Citation impact
- FWCI
- 361.44
- Percentile
- 100%
- References
- 87
Authors
11- RJRalf J. LudwigCorresponding
University Hospital Schleswig-Holstein, University of Lübeck
- MAMatthew Anson
University of Liverpool, Aintree University Hospitals NHS Foundation Trust
- HZHenner Zirpel
University Hospital Schleswig-Holstein, University of Lübeck
- DTDiamant Thaçi
University Hospital Schleswig-Holstein, University of Lübeck
- HOHenning Olbrich
University Hospital Schleswig-Holstein, University of Lübeck
Topics & keywords
- Generalizability theory
- Data science
- Health care
- Context (archaeology)
- Leverage (statistics)
- Real world data
- Analytics
- Psychological intervention
- Reduced inequalities