articleAnalytical ChemistryMar 10, 2025Closed access

Electrochemical Sensing of Perfluorooctanoic Acid via a Rationally Designed Fluorine-Functionalized Cu-MOF and In-Depth Analysis of Sensing Mechanism

Key Laboratory of Guangdong Province · Zhangzhou Normal University · +2 more institutions

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Abstract

Perfluorooctanoic acid (PFOA), a prominent member of the per- and polyfluoroalkyl substance (PFAS) family, has emerged as a new perpetual pollutant posing significant environmental and health risks, necessitating developing highly selective materials for its sensitive detection in water. In this work, we developed an electroactive fluorine-functionalized Cu-MOF (F–Cu–NH2BDC) through postmodification of the copper-2-amino-terephthalic acid (Cu–NH2BDC) MOF with 2,3,5,6-tetrafluoroterephthalaldehyde (TFTA). Experimental and computational results suggested that F–F interactions between the decorated tetrafluorobenzaldehyde groups and PFOA, as well as among the PFOA molecules themselves, would induce…

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