Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

Chen, Jianzhou; Lévy, Antonin; Tian, Ai-Ling; Huang, Xuehan; Cai, Guoxin; Fidelle, Marine; Rauber, Conrad; Ly, Pierre; Pizzato, Eugénie; Sitterlé, Lisa; Piccinno, Gianmarco; Liu, Peng; Durand, Sylvère; Mao, Misha; Zhao, Liwei; Iebba, Valerio; Felchle, Hannah; Varende, Anne-Laure Mallard de La; Fischer, Julius; Thomas, Simon; Greten, Tim F.; Jones, Jennifer; Monge, Cecilia; Demaria, Sandra; Formenti, Silvia C.; Belluomini, Lorenzo; Dionisi, Valeria; Massard, Christophe; Blanchard, Pierre‐Yves; Robert, Charlotte; Quevrin, Clément; Lopes, Eloise; Clémenson, Céline; Mondini, Michele; Meziani, Lydia; Zhan, Yizhou; Zeng, Chengbing; Cai, Qingxin; Morel, Daphné; Sun, Roger; Laurent, Pierre-Antoine; Mangoni, Monica; Cataldo, Vanessa Di; Arilli, C.; Trommer, Maike; Wegen, Simone; Neppl, Sebastian; Riechelmann, Rachel P.; Camandaroba, Marcos Pedro Guedes; Neto, Elson Santos; Fournier, Pierre‐Edouard; Segata, Nicola; Holíček, Peter; Galluzzi, Lorenzo; Buqué, Aitziber; Silva, Carolina Alves Costa; Derosa, Lisa; Kroemer, Guido; Chen, Chuangzhen; Zitvogel, Laurence; Deutsch, Éric

doi:10.1016/j.ccell.2025.02.010

articleCancer CellMar 1, 2025HYBRID OA

Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

JCJianzhou Chen ALAntonin Lévy ATAi-Ling Tian XHXuehan Huang GCGuoxin Cai

Inserm · Université Paris-Saclay · +37 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

T cell activation without exhaustion. Various strains of Christensenella minuta selectively boost the anti-cancer efficacy of ILDR and PD-L1 blockade, allowing emigration of intestinal PD-L1-expressing dendritic cells to tumor-draining lymph nodes. An interventional phase 2 study provides the proof-of-concept that ILDR can circumvent resistance to first- or second-line immunotherapy in cancer patients. Prospective clinical trials are warranted to define optimal dosimetry and indications for ILDR to maximize its therapeutic potential.

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Percentile: 100%
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Topics & keywords

Topics

Keywords

Blockade
Medicine
Cancer
Cancer research
Pharmacology
Oncology
Internal medicine
Receptor

UN Sustainable Development Goals

Good health and well-being

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