reviewJournal of Clinical MedicineMar 8, 2025GOLD OA

Bone Regeneration: A Review of Current Treatment Strategies

RDRaffaella De PaceSMSilvia MolinariEMElisa MazzoniGPGiuseppe Perale

University of Ferrara · Vir Biotechnology (Switzerland) · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Bone regeneration has emerged as a critical research and clinical advancement field, fueled by the growing demand for effective treatments in orthopedics and oncology. Over the past two decades, significant progress in biomaterials and surgical techniques has led to the development of novel solutions for treating bone defects, surpassing the use of traditional autologous grafts. This review aims to assess the latest approaches in bone regeneration, including autologous, allogenic, and xenogenic grafts, naturally derived biomaterials, and innovative synthetic substitutes such as bioceramics, bioactive glasses, metals, polymers, composite materials, and other specialized applications. A comprehensive literature…

Citation impact

105
total citations
FWCI
55.24
Percentile
100%
References
261
Citations per year

Authors

4

Topics & keywords

Keywords
  • Medicine
  • Regeneration (biology)
  • Clinical Practice
  • Intensive care medicine
  • Medical physics
  • Physical therapy
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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